Rare occurrence of type 2 diabetes mellitus in patients with sickle cell anaemia: assessing the contribution of inflammation, insulin resistance and glucose buffering capacity of abnormal haemoglobin

This review was designed to discuss the rare occurrence of diabetes mellitus (DM) in patients with sickle cell anaemia (SCA) a particular focus on factors, such as life expectancy, body weight, chronic inflammation, insulin resistance, glucose buffering property haemoglobin, and microRNAs (miRNAs), aiming stimulate research which will fill existing knowledge gaps regarding interplay between SCA DM. Additionally, possible pharmacotherapeutic approaches DM were also highlighted review. Google Scholar PubMed search engines used for relevant keywords, trait, disease, anaemia, mellitus. appear have β-cell dysfunction reduced secretion, but present similar sensitivity status other without haemoglobinopathy. Glucose haemoglobin DM-protective roles miRNAs sickled erythrocytes constitute some potential factors protecting from developing Sickle is associated several complications endocrinopathies, nevertheless, its coexistence continues be observation. Proper elucidation mechanisms seemingly confer ‘protection’ against may provide therapeutic insights